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Results and Discussion Early Recognition of Symptoms of Peripheral Neuropathy PN symptoms, which may manifest during diabetes diagnosis or prediabetes, pose a challenge for early recognition due to their vague nature, often mistaken for aging or unrelated conditions [33]

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Payers should also note that the increased drug costs of LAI use may be offset by lower medical costs resulting from fewer psychiatric hospitalizations [33]

Together, providing the innate harmful effect of NOS blocker L-NAME itself, these findings may emphasize the positive significance of NO in protecting retinal neurons (and thereby, harmful effect of NOS-blockers ( Furthermore, it was demonstrated that NO is continuously produced in the retina and essential for maintenance of retinal blood flow (Vukojevic et al., 2018

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